Unlocking the Brain’s Potential: How Psychedelic Drugs Reset the Mind

Psychedelic Mushrooms


Psychedelic drugs have captured the attention of researchers due to their promising therapeutic effects on various mental health conditions. While their benefits are well-known, the precise mechanisms behind these effects remain largely unexplored. However, a recent study conducted on mice suggests that psychedelic substances share a common trait – they can reset the brain to a more youthful state, enabling improved learning and the formation of vital neuronal connections. This discovery holds the potential to revolutionize the treatment of behavioral, learning, and sensory disruptions associated with mental health disorders. Although further research is needed to fully comprehend the remodeling of brain connections by these drugs, the findings open exciting possibilities for therapeutic interventions.

Temporary Psychedelic Use, Lifelong Benefits?

Psychedelics, including MDMA (ecstasy), ketamine, and psilocybin (found in magic mushrooms), are renowned for their mind-altering effects, often leading to hallucinations. However, what has intrigued scientists is the long-lasting positive impact of these substances on conditions such as depression and addiction, despite their distinct biochemical pathways. Seeking answers, a team by neuroscientists at Johns Hopkins University delved into how psychedelics influence social behavior in mice.

During adolescence, mice can associate social interactions with positive experiences, but this critical period diminishes as they mature into adulthood. Previous research demonstrated that administering MDMA to adult mice in the presence of others reopened the critical period, making them more inclined to choose social settings. Building upon this finding, the researchers expanded their investigation to include other psychedelic compounds such as ibogaine, LSD, ketamine, and psilocybin. Surprisingly, mice treated with any of these substances displayed a preference for the social environment, indicating the potential reopening of critical periods.

The Role Of Context on Psychedelics

Interestingly, the study revealed that the effects of these drugs on critical periods depended on the social context in which they were administered. For instance, mice did not exhibit a preference for the social environment when given a dosage of ketamine that rendered them unconscious. This suggests that the drugs’ impact on critical periods is influenced by the level of social engagement during administration. The findings propose a mechanistic relationship between critical period reopening and the altered state of consciousness induced by psychedelics.

Decoding the Biological Mechanisms in Psychedelics

To gain deeper insights into the biological mechanisms behind the effects of psychedelics, the researchers examined the brains of the mice. They discovered heightened sensitivity to oxytocin, commonly known as the “love hormone,” in specific brain regions. This increased sensitivity was attributed to a state called metaplasticity, which enhances neuronal receptivity to stimuli and facilitates rewiring and the formation of new connections. Additionally, gene expression changes related to the regulation of protein matrix on neuron surfaces were observed, potentially enabling growth and the establishment of new connections.

Psychedelics: A Master Key?

Based on these findings, the researchers propose that psychedelic drugs act as a master key capable of unlocking various types of critical periods by inducing metaplasticity in neurons. The outcome, however, is contingent on the contextual factors present during drug administration, emphasizing the significance of social engagement. These intriguing insights offer hope that a comprehensive understanding of the cellular effects of psychedelic drugs may pave the way for novel approaches to reopening brain plasticity, thereby revolutionizing the treatment of various conditions.

While the study presents groundbreaking findings, further research is imperative to unravel the intricate mechanisms underlying the effects of psychedelic drugs on critical periods. Experts suggest exploring the effects of these drugs in different brain regions and investigating their potential to reopen critical periods beyond sociability. However, not all experts share the same level of optimism,

with some expressing skepticism about the drugs’ role in inducing metaplasticity and suggesting that their effects might be attributed to physical changes in neuronal connections rather than enhanced receptivity to environmental stimuli.


The recent study shedding light on the resetting properties of psychedelic drugs offers a promising avenue for future research and therapeutic applications. By unraveling the intricate mechanisms of critical period reopening and neuronal rewiring, scientists have taken a significant step toward harnessing the potential of these substances for the treatment of mental health disorders. While there is still much to learn, the study opens the door to a new era of psychedelic medicine and the exploration of brain plasticity-enhancing interventions that could transform the lives of individuals with various conditions.


Nardou, R. et al. Nature https://doi.org/10.1038/s41586-023-06204-3(2023).

Goodwin, G. M. et al. N. Engl. J. Med. 387, 1637–1648 (2022).

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